Objective: What is the role of the cerebello-striato-cortical interactions?​

• In reward-based motor learning (short-time scale)?​
• In the recall of motor programs (across sessions time scale)?​‍

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Methods​

• In patients with ADCY5 mutations: Striatal dysfunction​
• In patients with PRRT2 and SGCE mutations: Cerebellar dysfunction​
• In healthy volunteers: Neuromodulation (TMS) of the cerebellum​
• + In animal model of dystonia:  Mice with ADCY5/SGCE mutation​

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Expected results​

• Cerebello-striatal loops play a role in immediate reward-based motor learning​
• Striato-cerebellar loops play a role in recall of motor programs ​

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