Objective: To study the dynamics of corticospinal development​

What are​

• The molecular scenarios?​
• The links between molecular defects, corticospinal development, and motor dysfunction?​

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How: Translational approach in patients and mouse models to study​

• The genome-wide genetics and epigenetics in our cohort​
• The molecular roles of CMM genes in the corticospinal tract (in vitro/in vivo)​
• The consequence of the defect on motor function (mice/patients)​

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Expected results​

• Identify new genetic and epigenetic causes of CMM​
• Understand the molecular mechanism of corticospinal tract defects​
• Modifications of cognitive processes associated with motor control​

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